Table 3. Univariate and multivariate analysis of factors associated with poor overall survival or poor recurrence-free survival in patients with Ishak stage 1–5 (a) and Ishak stage 6 (b).
Overall survival |
Recurrence-free survival |
|||||
---|---|---|---|---|---|---|
|
Univariate |
Multivariate |
Univariate |
Multivariate |
||
P-value | HR (95% CI) | P-value | P-value | HR (95% CI) | P-value | |
(a) | ||||||
Gender (male) | 0.10 | 0.18 | ||||
Age (>56) | 0.63 | 0.91 | ||||
Race (Asian) | 0.13 | 0.62 | ||||
Poorly differentiated tumour | 0.005 | 0.018 | ||||
Microvascular invasion | 0.34 | 0.027 | ||||
Macrovascular invasion | 0.21 | 0.009 | ||||
Tumour number >1 | 0.84 | 0.62 | ||||
Tumour size (cm) | 0.001 | 1.16 (1.06–1.26) | 0.001 | <0.001 | 1.10 (1.04–1.16) | <0.001 |
Resection margin | 0.011 | 0.54 | ||||
Detectable circulating HBV DNA | 0.17 | 0.71 | ||||
ALT (>30 units l−1) | 0.002 | 0.039 | ||||
AFP (>20 ng ml−1) | 0.02 | 0.014 | 1.85 (1.08–3.18) | 0.02 | ||
HAI grade | 0.32 | 0.004 | 1.20 (1.06–1.37) | 0.005 | ||
Ishak stage |
0.38 |
|
|
0.99 |
|
|
(b) | ||||||
Gender (male) | 0.25 | 0.17 | ||||
Age (>56) | 0.29 | 0.97 | ||||
Race (Asian) | 0.028 | 0.05 | ||||
Poorly differentiated tumour | 0.003 | 3.20 (1.27–8.05) | 0.01 | 0.026 | ||
Microvascular invasion | 0.02 | 0.70 | ||||
Macrovascular invasion | <0.001 | <0.001 | ||||
Tumour number >1 | 0.26 | 0.97 | ||||
Tumour size (cm) | 0.002 | 1.16 (1.04–1.29) | 0.006 | 0.013 | 1.14 (1.03–1.26) | 0.01 |
Resection margin | 0.56 | 0.31 | ||||
Detectable circulating HBV DNA | 0.85 | 0.85 | ||||
ALT (>30 units l−1) | 0.32 | 0.42 | ||||
AFP (>20 ng ml−1) | 0.02 | 0.32 | ||||
HAI grade | 0.66 | 0.20 |
Abbreviations: HAI=histologic activity index; HBV=hepatitis B virus; HR=hazard ratio.