Table 3. Univariate and multivariate analysis of factors associated with poor overall survival or poor recurrence-free survival in patients with Ishak stage 1–5 (a) and Ishak stage 6 (b).

	Overall survival			Recurrence-free survival
	Univariate	Multivariate		Univariate	Multivariate
	P-value	HR (95% CI)	P-value	P-value	HR (95% CI)	P-value
(a)
Gender (male)	0.10			0.18
Age (>56)	0.63			0.91
Race (Asian)	0.13			0.62
Poorly differentiated tumour	0.005			0.018
Microvascular invasion	0.34			0.027
Macrovascular invasion	0.21			0.009
Tumour number >1	0.84			0.62
Tumour size (cm)	0.001	1.16 (1.06–1.26)	0.001	<0.001	1.10 (1.04–1.16)	<0.001
Resection margin	0.011			0.54
Detectable circulating HBV DNA	0.17			0.71
ALT (>30 units l−1)	0.002			0.039
AFP (>20 ng ml−1)	0.02			0.014	1.85 (1.08–3.18)	0.02
HAI grade	0.32			0.004	1.20 (1.06–1.37)	0.005
Ishak stage	0.38			0.99
(b)
Gender (male)	0.25			0.17
Age (>56)	0.29			0.97
Race (Asian)	0.028			0.05
Poorly differentiated tumour	0.003	3.20 (1.27–8.05)	0.01	0.026
Microvascular invasion	0.02			0.70
Macrovascular invasion	<0.001			<0.001
Tumour number >1	0.26			0.97
Tumour size (cm)	0.002	1.16 (1.04–1.29)	0.006	0.013	1.14 (1.03–1.26)	0.01
Resection margin	0.56			0.31
Detectable circulating HBV DNA	0.85			0.85
ALT (>30 units l−1)	0.32			0.42
AFP (>20 ng ml−1)	0.02			0.32
HAI grade	0.66			0.20

Abbreviations: HAI=histologic activity index; HBV=hepatitis B virus; HR=hazard ratio.