Table 5. Comparison of adverse events between BMI categories stratified by treatment.
|
Control |
Anastrozole |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| |
Norm (n=87) |
Over (n=253) |
Norm (n=90) |
Over (n=204) |
|
||||
| Adverse event | N | % | N | % | N | % | N | % | P-value |
| Allergy |
1 |
1.1 |
1 |
0.4 |
3 |
3.3 |
5 |
2.5 |
0.467 |
| Amenorrhoea |
85 |
97.7 |
245 |
96.8 |
84 |
93.3 |
192 |
94.1 |
0.976 |
| Arrhythmia |
3 |
3.4 |
3 |
1.2 |
4 |
4.4 |
8 |
3.9 |
0.344 |
| Asthenia |
3 |
3.4 |
2 |
0.8 |
5 |
5.6 |
9 |
4.4 |
0.211 |
| Bleeding |
1 |
1.1 |
1 |
0.4 |
2 |
2.2 |
1 |
0.5 |
0.119 |
| Bone aches |
25 |
28.7 |
50 |
19.8 |
26 |
28.9 |
57 |
27.9 |
0.190 |
| Card disorders |
5 |
5.7 |
17 |
6.7 |
2 |
2.2 |
13 |
6.4 |
0.222 |
| Cutaneous toxicity |
0 |
0.0 |
1 |
0.4 |
6 |
6.7 |
10 |
4.9 |
0.647 |
| Depressions |
10 |
11.5 |
21 |
8.3 |
17 |
18.9 |
33 |
16.2 |
0.319 |
| Diarrhoea |
3 |
3.4 |
7 |
2.8 |
5 |
5.6 |
12 |
5.9 |
0.918 |
| Eczema |
1 |
1.1 |
6 |
2.4 |
1 |
1.1 |
12 |
5.9 |
0.058 |
| Fever |
1 |
1.1 |
4 |
1.6 |
3 |
3.3 |
5 |
2.5 |
0.866 |
| Headache |
10 |
11.5 |
30 |
11.9 |
20 |
22.2 |
44 |
21.6 |
0.967 |
| Haematuria |
0 |
0.0 |
2 |
0.8 |
1 |
1.1 |
3 |
1.5 |
0.505 |
| Hair loss |
1 |
1.1 |
8 |
3.2 |
12 |
13.3 |
20 |
9.8 |
0.746 |
| Hot flushes |
18 |
20.7 |
61 |
24.1 |
42 |
46.7 |
82 |
40.2 |
0.725 |
| Infections |
2 |
2.3 |
6 |
2.4 |
5 |
5.6 |
9 |
4.4 |
0.749 |
| Nausea |
2 |
2.3 |
6 |
2.4 |
9 |
10.0 |
13 |
6.4 |
0.358 |
| Obstipation |
2 |
2.3 |
9 |
3.6 |
8 |
8.9 |
14 |
6.9 |
0.858 |
| Pericarditis |
0 |
0.0 |
0 |
0.0 |
1 |
1.1 |
0 |
0.0 |
0.132 |
| Proteinuria |
0 |
0.0 |
1 |
0.4 |
1 |
1.1 |
1 |
0.5 |
0.866 |
| Somnolence |
4 |
4.6 |
12 |
4.7 |
9 |
10.0 |
26 |
12.7 |
0.557 |
| Vaginal discharge |
6 |
6.9 |
5 |
2.0 |
5 |
5.6 |
16 |
7.8 |
0.480 |
| Vaginal dryness |
11 |
12.6 |
20 |
7.9 |
16 |
17.8 |
23 |
11.3 |
0.045 |
| Vomiting |
2 |
2.3 |
5 |
2.0 |
3 |
3.3 |
5 |
2.5 |
0.659 |
| Other | 28 | 32.2 | 82 | 32.4 | 42 | 46.7 | 78 | 38.2 | 0.345 |
Abbreviation: BMI=body mass index.