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. 2013 Jul 16;109(3):552–558. doi: 10.1038/bjc.2013.368

Table 2. Haematological and non-haematological toxicity by patient (N=76).

Toxicity Grade 1 (No.) Grade 2 (No.) Grade 3 (No.) Grade 4 (No.) Grade 3–4 (%)
Haematological toxicity
Neutropaeniaa 3 5 2 4 8
Anaemia 12 20 3 4
Thrombocytopaenia
2
2
2

3
Non-haematological toxicityb,c
Nausea-vomiting 28 14 2 3
Fatigue 24 16 6 8
Mucositis 22 5 2 3
Diarrhoea 7 4 0
Constipation 17 8 2 3
Anorexia 9 3 0
Nephrotoxicity 5 1 1 1
Pneumonitis 1 1c 3
Hypertension 12 7 2 3
Thrombosis (arterial) 1 1 1 1
Bowel perforation 2 1c 4
Bleeding 14 1 1 1
a

Febrile neutropaenia was reported in two patients.

b

Other toxicities reported as rare events were grade 2–3 hepatotoxicity (two cases); grade 3 hyperkalaemia (one case) and grade 3 hyperglicemia (one case).

c

Three toxic deaths were reported: one case for bowel perforation, one case for pneumonitis with a documented H1N1 viral infection, one for a sudden death at home (autopsy not performed).