Table 2. Haematological and non-haematological toxicity by patient (N=76).
| Toxicity | Grade 1 (No.) | Grade 2 (No.) | Grade 3 (No.) | Grade 4 (No.) | Grade 3–4 (%) |
|---|---|---|---|---|---|
|
Haematological toxicity | |||||
| Neutropaeniaa | 3 | 5 | 2 | 4 | 8 |
| Anaemia | 12 | 20 | 3 | — | 4 |
| Thrombocytopaenia |
2 |
2 |
2 |
— |
3 |
|
Non-haematological toxicityb,c | |||||
| Nausea-vomiting | 28 | 14 | 2 | — | 3 |
| Fatigue | 24 | 16 | 6 | — | 8 |
| Mucositis | 22 | 5 | 2 | — | 3 |
| Diarrhoea | 7 | 4 | — | — | 0 |
| Constipation | 17 | 8 | 2 | — | 3 |
| Anorexia | 9 | 3 | — | — | 0 |
| Nephrotoxicity | 5 | 1 | — | 1 | 1 |
| Pneumonitis | — | — | 1 | 1c | 3 |
| Hypertension | 12 | 7 | 2 | — | 3 |
| Thrombosis (arterial) | 1 | 1 | 1 | — | 1 |
| Bowel perforation | — | — | 2 | 1c | 4 |
| Bleeding | 14 | 1 | 1 | — | 1 |
a
Febrile neutropaenia was reported in two patients.
b
Other toxicities reported as rare events were grade 2–3 hepatotoxicity (two cases); grade 3 hyperkalaemia (one case) and grade 3 hyperglicemia (one case).
c
Three toxic deaths were reported: one case for bowel perforation, one case for pneumonitis with a documented H1N1 viral infection, one for a sudden death at home (autopsy not performed).