Table 1. Demographic and clinicopathologic characteristics by with or without an FD-FH-NPC.
| |
With FD-FH-NPC (n=207) |
Without FD-FH-NPC (n=1566) |
|
||
|---|---|---|---|---|---|
| Characteristics | No. | % | No. | % | P-value |
|
Age group (years) |
|
|
|
|
0.723 |
| 20–30 | 8 | 3.9 | 94 | 6.0 | |
| 31–40 | 62 | 30.0 | 424 | 27.1 | |
| 41–50 | 67 | 32.4 | 503 | 32.1 | |
| 51–60 | 47 | 22.7 | 363 | 23.2 | |
| ⩾61 |
23 |
11.1 |
182 |
11.6 |
|
|
Gender |
|
|
|
|
0.171 |
| Male | 148 | 71.5 | 1188 | 75.9 | |
| Female |
59 |
28.5 |
378 |
24.1 |
|
|
Education degree |
|
|
|
|
0.237 |
| Illiterate | 11 | 5.3 | 84 | 5.4 | |
| Primary | 56 | 27.1 | 516 | 33.0 | |
| Secondary | 105 | 50.7 | 763 | 48.7 | |
| Higher |
35 |
16.9 |
203 |
13.0 |
|
|
Smoking statusa |
|
|
|
|
0.806 |
| Current smoker | 77 | 37.2 | 619 | 39.5 | |
| Former smoker | 21 | 10.1 | 149 | 9.5 | |
| Never smoker |
109 |
52.7 |
798 |
51.0 |
|
|
Drinking statusa |
|
|
|
|
0.766 |
| Current drinker | 24 | 11.6 | 207 | 13.2 | |
| Former drinker | 4 | 1.9 | 25 | 1.6 | |
| Never drinker |
179 |
86.5 |
1334 |
85.2 |
|
|
VCA-IgA |
|
|
|
|
0.495 |
| ⩽1 : 160 | 107 | 51.7 | 770 | 49.2 | |
| >1 : 160 |
100 |
48.3 |
796 |
50.8 |
|
|
Pathologyb |
|
|
|
|
0.315c |
| I | 0 | 0 | 6 | 0.4 | |
| II | 7 | 3.4 | 86 | 5.5 | |
| III |
200 |
96.6 |
1474 |
94.1 |
|
|
T stage |
|
|
|
|
0.001 |
| T1 | 36 | 17.4 | 205 | 13.1 | |
| T2 | 72 | 34.8 | 398 | 25.4 | |
| T3 | 70 | 33.8 | 589 | 37.6 | |
| T4 |
29 |
14.0 |
374 |
23.9 |
|
|
N stage |
|
|
|
|
0.002 |
| N0 | 50 | 24.2 | 263 | 16.8 | |
| N1 | 124 | 59.9 | 883 | 56.4 | |
| N2 | 29 | 14.0 | 377 | 24.1 | |
| N3 |
4 |
1.9 |
43 |
2.7 |
|
|
Clinical stage |
|
|
|
|
<0.001 |
| I | 16 | 7.7 | 71 | 4.5 | |
| II | 76 | 36.7 | 396 | 25.3 | |
| III | 82 | 39.6 | 690 | 44.1 | |
| IVa | 29 | 14.0 | 366 | 23.4 | |
| IVb |
4 |
1.9 |
43 |
2.7 |
|
|
Chemotherapy regimens |
|
|
|
|
<0.001c |
| None | 70 | 33.8 | 357 | 22.8 | |
| IC | 27 | 13.0 | 412 | 26.3 | |
| CCRT | 69 | 33.3 | 429 | 27.4 | |
| IC+CCRT | 33 | 15.9 | 292 | 18.6 | |
| CCRT+AC | 5 | 2.4 | 58 | 3.7 | |
| IC+CCRT+AC |
3 |
1.4 |
18 |
1.1 |
|
|
Radiation technique |
|
|
|
|
0.943c |
| IMRT | 49 | 23.7 | 375 | 23.9 | |
| 3DCRT | 5 | 2.4 | 31 | 2.0 | |
| Conventional | 153 | 73.9 | 1160 | 74.1 | |
Abbreviations: AC=adjuvant chemotherapy; CCRT=concurrent chemoradiotherapy; FD-FH-NPC=first-degree family history of nasopharyngeal carcinoma; IC=induction chemotherapy; IMRT=intensity-modulated radiotherapy; VCA-IgA=immunoglobulin A against Epstein–Barr virus viral capsid antigen; WHO=World Health Organization; 3DCRT=three-dimensional conformal radiotherapy.
Current smokers/drinkers are defined as patients who smoke/drink at diagnosis or have stopped for <1 year. Former smokers/drinkers are patients who have stopped smoking or drinking for at least 1 year before treatment.
Based on the criteria of WHO histological type (1991): I=squamous cell carcinomas; II=differentiated non-keratinising carcinoma; III=undifferentiated non-keratinising carcinoma.
P-values by Fisher's exact probability test and all others by Pearson's χ2 test.