Table 2. Multivariate analysis for OS, LRFS and DMFSa.
| |
|
OS |
LRFS |
DMFS |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. at risk | No. of events | aHR (95% CI) | P-value | No. of events | aHR (95% CI) | P-value | No. of events | aHR (95% CI) | P-value | |
|
FD-FH-NPC | ||||||||||
| Without | 1566 | 338 | 1.00 | 148 | 1.00 | 213 | 1.00 | |||
| With |
207 |
20 |
0.60 (0.37–0.98) |
0.040 |
11 |
0.52 (0.24–1.12) |
0.096 |
13 |
0.51 (0.27–0.97) |
0.040 |
|
A second- or third-degree family history of NPC | ||||||||||
| No | 1721 | 352 | 1.00 | 157 | 1.00 | 224 | 1.00 | |||
| Yes |
52 |
6 |
0.92 (0.41–2.08) |
0.841 |
2 |
0.61 (0.15–2.47) |
0.486 |
2 |
0.39 (0.10–1.58) |
0.186 |
|
Number of first-degree relatives with NPC | ||||||||||
| 0 | 1566 | 338 | 1.00 | 148 | 1.00 | 213 | 1.00 | |||
| 1 | 173 | 17 | 0.61 (0.36–1.02) | 0.059 | 9 | 0.52 (0.23–1.18) | 0.118 | 11 | 0.53 (0.27–1.03) | 0.062 |
| ⩾2 |
34 |
3 |
0.57 (0.14–2.28) |
0.423 |
2 |
0.54 (0.07–3.88) |
0.538 |
2 |
0.41 (0.06–2.91) |
0.369 |
|
FD-FH-NPC in stage I and II patients | ||||||||||
| Without | 467 | 43 | 1.00 | 31 | 1.00 | 22 | 1.00 | |||
| With |
92 |
3 |
0.31 (0.07–1.34) |
0.117 |
4 |
0.39 (0.05–2.99) |
0.364 |
2 |
0.31 (0.04–2.35) |
0.257 |
|
FD-FH-NPC in stage III and IV patients | ||||||||||
| Without | 1099 | 295 | 1.00 | 117 | 1.00 | 191 | 1.00 | |||
| With | 115 | 17 | 0.57 (0.34–0.95) | 0.033 | 7 | 0.54 (0.24–1.23) | 0.143 | 11 | 0.49 (0.25–0.96) | 0.036 |
Abbreviations: aHR=adjusted hazard ratio; CI=confidence interval; DMFS=distant metastasis-free survival; FD-FH-NPC=first-degree family history of nasopharyngeal carcinoma; LRFS=locoregional relapse-free survival; NPC=nasopharyngeal carcinoma; OS=overall survival.
a
Multivariate HRs and 95% CIs are adjusted for age group (categorical), gender, education degree (categorical), smoking status (never/current/former smoker), drinking status (never/current/former drinker), pathology (I/II/III), T stage (T1/T2/T3/T4), N stage (N0/N1/N2/N3), titre of VCA-IgA (⩽1 : 160 vs >1 : 160), chemotherapy regimens and radiation technique.