Table 3. Bisphosphonate short- and long-term use in cancer cases and controls, numbers and odds ratios (95% CIs) compared with non-use by database.
|
Cancer site |
QResearch |
CPRD |
Combined analysis |
|||||
|---|---|---|---|---|---|---|---|---|
| Terms of use | Cases/controls | Adjusted*odds ratio (95% CI) | P-value | Cases/controls | Adjusted*odds ratio (95% CI) | P-value | Pooled odds ratio (95% CI) | P-value |
| Breast |
Trend |
|
0.5 |
Trend |
|
0.3 |
Trend |
0.2 |
| Short term (less than a year) | 462/2523 | 0.86 (0.77–0.97) | 0.01 | 508/2620 | 0.95 (0.86–1.06) | 0.4 | 0.91 (0.84–0.98) | 0.02 |
| Long term (at least a year) |
842/4400 |
0.91 (0.83–1.00) |
0.05 |
816/4227 |
0.95 (0.86–1.04) |
0.3 |
0.93 (0.87–0.99) |
0.03 |
| Prostate |
Trend |
|
0.06 |
Trend |
|
0.03 |
Trend |
0.005 |
| Short term (less than a year) | 186/838 | 0.95 (0.80–1.13) | 0.6 | 149/764 | 0.84 (0.70–1.02) | 0.07 | 0.90 (0.79–1.02) | 0.1 |
| Long term (at least a year) |
274/1312 |
0.86 (0.74–1.00) |
0.06 |
227/1137 |
0.84 (0.71–0.99) |
0.04 |
0.85 (0.76–0.95) |
0.005 |
| Lung |
Trend |
|
0.7 |
Trend |
|
1.0 |
Trend |
0.8 |
| Short term (less than a year) | 415/1351 | 1.04 (0.90–1.19) | 0.6 | 467/1507 | 1.15 (1.01–1.32) | 0.03 | 1.10 (1.00–1.21) | 0.06 |
| Long term (at least a year) |
620/2458 |
0.93 (0.82–1.05) |
0.2 |
647/2404 |
1.09 (0.96–1.23) |
0.2 |
1.01 (0.92–1.10) |
0.9 |
| Bladder |
Trend |
|
0.3 |
Trend |
|
0.6 |
Trend |
0.3 |
| Short term (less than a year) | 109/455 | 0.99 (0.79–1.26) | 1.0 | 117/464 | 1.06 (0.84–1.33) | 0.6 | 1.03 (0.87–1.21) | 0.8 |
| Long term (at least a year) |
165/764 |
0.93 (0.76–1.15) |
0.5 |
163/799 |
0.86 (0.69–1.06) |
0.2 |
0.90 (0.77–1.04) |
0.2 |
| Melanoma |
Trend |
|
0.01 |
Trend |
|
0.5 |
Trend |
0.02 |
| Short term (less than a year) | 77/400 | 0.91 (0.70–1.20) | 0.5 | 64/354 | 0.88 (0.65–1.18) | 0.4 | 0.90 (0.73–1.10) | 0.3 |
| Long term (at least a year) |
164/667 |
1.16 (0.92–1.45) |
0.2 |
114/527 |
1.01 (0.78–1.31) |
0.9 |
1.09 (0.92–1.29) |
0.3 |
| Ovaries |
Trend |
|
0.4 |
Trend |
|
0.1 |
Trend |
0.7 |
| Short term (less than a year) | 83/322 | 1.37 (1.04–1.81) | 0.02 | 62/355 | 0.80 (0.59–1.08) | 0.1 | 1.07 (0.87–1.31) | 0.5 |
| Long term (at least a year) |
121/617 |
1.08 (0.84–1.38) |
0.6 |
108/582 |
0.86 (0.66–1.11) |
0.2 |
0.96 (0.81–1.15) |
0.7 |
| Pancreas |
Trend |
|
0.2 |
Trend |
|
0.05 |
Trend |
0.02 |
| Short term (less than a year) | 63/316 | 0.78 (0.57–1.06) | 0.1 | 71/336 | 0.77 (0.57–1.02) | 0.07 | 0.77 (0.63–0.96) | 0.02 |
| Long term (at least a year) | 115/570 | 0.82 (0.63–1.06) | 0.1 | 125/582 | 0.80 (0.62–1.02) | 0.08 | 0.81 (0.67–0.97) | 0.02 |
Abbreviations: CI=confidence interval; CPRD=Clinical Practice Research Datalink. *Adjusted for the confounders listed in the footnote for Table 2. Bold values indicate statistical significance.