Table 4. Toxicity.
| |
Docetaxel+cisplatin (n=130) |
Maintenance chemotherapy using S-1 (n=109) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Toxicity | Toxicity grade | Toxicity grade | |||||||||
| |
1 |
2 |
3 |
4 |
%3–4 |
1 |
2 |
3 |
4 |
5 |
%3–5 |
|
Haematologic | |||||||||||
| Neutropaenia | 4 | 14 | 39 | 63 | 78.5 | 20 | 18 | 4 | 0 | 0 | 3.7 |
| Anaemia | 52 | 31 | 1 | 0 | 0.8 | 26 | 38 | 6 | 2 | 0 | 7.3 |
| Thrombocytopaenia |
30 |
6 |
0 |
0 |
0 |
35 |
0 |
0 |
0 |
0 |
0 |
|
Gastrointestinal | |||||||||||
| Anorexia | 55 | 47 | 22 | 0 | 16.9 | 43 | 21 | 4 | 0 | 0 | 3.7 |
| Vomiting | 23 | 20 | 5 | 0 | 3.8 | 11 | 5 | 1 | 0 | 0 | 0.9 |
| Diarrhoea | 35 | 11 | 15 | 0 | 11.5 | 19 | 3 | 1 | 0 | 0 | 0.9 |
| Mucositis |
12 |
4 |
0 |
0 |
0 |
23 |
7 |
0 |
0 |
0 |
0 |
|
Hepatic | |||||||||||
| AST | 14 | 5 | 2 | 0 | 1.5 | 25 | 5 | 0 | 0 | 0 | 0 |
| ALT |
25 |
9 |
1 |
0 |
0.8 |
24 |
4 |
0 |
0 |
0 |
0 |
|
Renal | |||||||||||
| Creatinine |
39 |
9 |
0 |
0 |
0 |
30 |
8 |
0 |
0 |
0 |
0 |
|
Neurologic | |||||||||||
| Neuropathy (sensory) |
9 |
4 |
0 |
0 |
0 |
19 |
2 |
2 |
0 |
0 |
1.8 |
|
Others | |||||||||||
| Hyponatraemia | 57 | — | 18 | 5 | 17.7 | 16 | — | 0 | 0 | 0 | 0 |
| Fatigue | 57 | 21 | 5 | 0 | 3.8 | 41 | 9 | 2 | 0 | 0 | 1.8 |
| Allergic reaction | 7 | 0 | 1 | 1 | 1.5 | 1 | 0 | 0 | 0 | 0 | 0 |
| Dehydration | 0 | 0 | 2 | 0 | 1.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Alopecia | 68 | 29 | 0 | 0 | 0 | 35 | 10 | 0 | 0 | 0 | 0 |
| Febrile neutropaenia | — | — | 10 | 0 | 7.7 | — | — | 0 | 0 | 0 | 0 |
| Infection with G3–4 neutropaenia | 0 | 3 | 5 | 0 | 3.8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Infection with G0–2 neutropaenia | 0 | 3 | 2 | 1 | 2.3 | 1 | 3 | 1 | 0 | 1 | 1.8 |
| Pneumonitis | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0.9 |
| Dyspnoea | 0 | 1 | 0 | 0 | 0 | 8 | 2 | 2 | 0 | 0 | 1.8 |
Abbreviations: ALT=alanine aminotransferase; AST=aspartate aminotransferase; G=grade.