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. Author manuscript; available in PMC: 2013 Aug 8.
Published in final edited form as: J Mol Endocrinol. 2012 Apr 2;48(3):R45–R53. doi: 10.1530/JME-12-0008

Figure 1.

Figure 1

(A) Schematic representation of the DLK1–MEG3 locus on human chromosome 14. The DLK1–MEG3 locus is w~837 kb long and consists of three known protein-coding genes including DLK1, RTL1, and DIO3, noncoding RNAs including at least three lncRNAs, and numerous small nucleolar RNAs (snoRNAs) and micro-RNAs (miRNAs). The maternal chromosome is in red and the paternal chromosome in blue. Differentially methylated regions are shown as circles. Filled circle, methylated; open circle, unmethylated. (B) The MEG3 gene is 35 kb long and consists of ten exons. The IG-DMR is ~13 kb upstream of the MEG3 gene. The MEG3-DMR overlaps with the MEG3 promoter.