(A) Schematic representation of the DLK1–MEG3 locus on human chromosome 14. The DLK1–MEG3 locus is w~837 kb long and consists of three known protein-coding genes including DLK1, RTL1, and DIO3, noncoding RNAs including at least three lncRNAs, and numerous small nucleolar RNAs (snoRNAs) and micro-RNAs (miRNAs). The maternal chromosome is in red and the paternal chromosome in blue. Differentially methylated regions are shown as circles. Filled circle, methylated; open circle, unmethylated. (B) The MEG3 gene is 35 kb long and consists of ten exons. The IG-DMR is ~13 kb upstream of the MEG3 gene. The MEG3-DMR overlaps with the MEG3 promoter.