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Systemic FasL neutralization in young and aged mice. (A) Young (12 weeks) or (B) aged (60 weeks) mice were laser treated and injected with Anti-CD178 (anti-FasL, LEAF) or IgG isotype control on the day of laser treatment (day 0), day 1, and day 2 (100 μg per injection per mouse in 150 μL of PBS). The volume of CNV lesions (expressed as volume of the fluorescence) was assessed on day 7. Asterisk (*) denotes significantly different from PBS-treated control. NS, not significant.
