Figure 5.

Relative changes of elasticity parameter, NO production, and PGI₂ release.

Notes: (A) Elasticity parameter (white-striped bars)/NO production (blue bars). (B) PGI₂ release for selected incubation conditions: TNF-α (1 hour [h]); TNF-α (4 hours); and TNF-α (1 hour) + MNA (3 hours). The relative changes of NO production/PGI₂ secretion were calculated compared to the control level (1.83 ± 0.4 μ M)/(5.97 ± 0.84 ng/mL) (mean ± SD). The statistically significant differences from the native samples are *P< 0.05 and **P< 0.01.

Abbreviations: TNF-α, tumor necrosis factor-alpha; MNA, 1-methylnicotinamide chloride; NO, nitric oxide; PGI₂, prostacyclin; SD, standard deviation.