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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2013 Aug;57(2):172–179. doi: 10.1097/MPG.0b013e318293e404

Table 2.

Liver Histopathology in NICU-Treated Baboons Versus Gestational Controls

[histology score ≥ moderate (2)]
Gestational
control
n=28		 NICU-
treated
n=45		 p
KC Hypertrophy 7.1% 97.8% <0.01
KC iron 0.0% 57.9% <0.01
Hemophagocytosis 0.0% 57.8% <0.01
Portal fibrosis 17.9% 46.7% <0.01
HC iron 64.3% 36.8% 0.05
HC Steatosis (macro) 10.7% 31.1% 0.05
HC Steatosis (micro) 7.1% 26.7% 0.06
Bile stasis 0.0% 20.0% 0.01
Ductular proliferation 0.0% 2.2% NS **

Liver histopathology (moderate or greater) in treated baboons. KC= Kupffer Cell. HC = Hepatocyte. Data are presented as percentage of treated baboons with tissue scores ≥ 2 (moderate pathology, see methods for scoring parameters) compared to complete range of gestational control ages.

**

while moderate or greater ductular proliferation was absent in controls and rare in treated samples, there was mild proliferation in 31% of treated animals vs 0% controls (P< 0.01)