. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: J Pediatr Gastroenterol Nutr. 2013 Aug;57(2):172–179. doi: 10.1097/MPG.0b013e318293e404

Table 2.

Liver Histopathology in NICU-Treated Baboons Versus Gestational Controls

	[histology score ≥ moderate (2)]

	Gestational control n=28	NICU- treated n=45	p
KC Hypertrophy	7.1%	97.8%	<0.01
KC iron	0.0%	57.9%	<0.01
Hemophagocytosis	0.0%	57.8%	<0.01
Portal fibrosis	17.9%	46.7%	<0.01
HC iron	64.3%	36.8%	0.05
HC Steatosis (macro)	10.7%	31.1%	0.05
HC Steatosis (micro)	7.1%	26.7%	0.06
Bile stasis	0.0%	20.0%	0.01
Ductular proliferation	0.0%	2.2%	NS	^**

Liver histopathology (moderate or greater) in treated baboons. KC= Kupffer Cell. HC = Hepatocyte. Data are presented as percentage of treated baboons with tissue scores ≥ 2 (moderate pathology, see methods for scoring parameters) compared to complete range of gestational control ages.

^**

while moderate or greater ductular proliferation was absent in controls and rare in treated samples, there was mild proliferation in 31% of treated animals vs 0% controls (P< 0.01)