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. 2012 May 31;1(2):cvd.2012.012007. doi: 10.1258/cvd.2012.012007

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© 2012 Royal Society of Medicine Press Ltd

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.0/), which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

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Synthesis of the fibrinogen receptor. (i) The subunits are transcribed from independent domains of chromosome 17q21.32, resulting in a pro-GPIIb moiety with heavy and light chains and a mature GPIIIa chain. (ii) The pro-GPIIb moiety is glycosylated and associates with the mature GPIIIa chain within the endoplasmic reticulum. (iii) Uncomplexed subunits are degraded by the calnexin cycle. (iv) Proteolytic cleavage of the pro-GPIIb subunit within the Golgi apparatus yields the mature GPIIb/IIIa. (v) Mature GPIIb/IIIa is transported to the plasma membrane or stored in alpha granules. G, glycoslation