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. 2013 Aug 8;9(8):e1003678. doi: 10.1371/journal.pgen.1003678

Figure 3. Disease activity QQ-Plots and the persistence of hypomethylation in quiescent patients.

Figure 3

A. QQ-Plots of the p-values from the flare versus quiescent association analysis for each cell type, illustrating the lack of activity-dependent DNA methylation. B. Boxplots of the methylation difference between each individual and the mean of all controls at CpGs in IFN-regulated genes among those that were highly significant in the SLE-control tests. The groups are labeled C, Control, F, SLE collected during a flare, and Q, SLE collected during quiescence.