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. 2013 Aug 8;9(8):e1003539. doi: 10.1371/journal.ppat.1003539

Figure 9. Sigirr −/− mice display strong antimicrobial activity against commensal microbes.

Figure 9

No significant differences were found between (A) the commensal microbiota found in WT and Sigirr −/− mice as measured by (B) qPCR and (C) FISH staining. Rapid commensal depletion in Sigirr −/− mice was observed as early as D1 pi by C. rodentium (D) and S. Typhimurium (E) while intestinal crypts isolated from Sigirr −/− mice (F) possess greater killing activity against commensal E. coli and Lactobacilli. Results are pooled from 2–3 independent experiments (or infections) with n = 3–5 per group. Error bars = SEM, (Student t test (Figure A) one way ANOVA (Figures B–F, *P<0.05, **P<0.01).