Fig. 2.

Relative contribution of glucose and oleate to mitochondrial acetyl-CoA formation for citrate synthesis and rates of glycolysis in working C57Bl/6 mouse hearts perfused in the absence (control) or in the presence of IVA with or without atrial pacing. Data are expressed as means ± SE of 4 –5 hearts perfused for 40 min with [U-¹³C₁₈]oleate or [U-¹³C₆]glucose. The contribution to acetyl-CoA formation of 1) glucose via pyruvate decarboxylation (PDC_Glc) and 2) oleate via β-oxidation (OLE) are expressed relative to citrate synthesis (CS). Details about the calculations of these flux ratios and glycolytic rates are in MATERIALS AND METHODS. *Substrates that were labeled with carbon 13. OAA, oxaloacetate.