Figure 7. Down-regulation of miR-21 with antagomir-21 inhibits angiogenesis through targeting HIF-1α/VEGF/VEGFR2 signaling pathway.

(A)Expression levels of miR-21 in tumors treated with miR-21 mimic, antagomir-21 or scramble. Data are expressed as mean ± SEM. **P<0.01 vs control group. (B–E) Protein levels of PTEN, HIF-1α, VEGF and VEGFR2 were analyzed by Western blotting assay. Data are expressed as mean ± SEM. n = 3 in each group. *P<0.05 vs control group, **P<0.01 vs control group.