Table 3. Number of cases (N) and percentages of observed and expected genotypes of ESR1 PvuII, CYP2C19 and UGT2B15 in tamoxifen-treated patients.
N observed | % observed | N expected | % expected | P | |
---|---|---|---|---|---|
ESR1 PvuII | |||||
wt/wt | 22 | 32 | 20.4 | 29.5 | 0.43 |
wt/vt | 31 | 45 | 34.2 | 49.6 | |
vt/vt | 16 | 23 | 14.4 | 20.8 | |
Total | 69 | 100 | 69 | 100 | |
CYP2C19 | |||||
wt/wt | 57 | 83 | 55.7 | 80.7 | 0.09 |
wt/*2 | 10 | 14 | 12.6 | 18.2 | |
*2/*2 | 2 | 3 | 0.7 | 1 | |
Total | 69 | 100 | 69 | 100 | |
UGT2B15 | |||||
wt/wt | 20 | 29 | 19.8 | 28.8 | 0.94 |
wt/*2 | 34 | 49 | 34.4 | 49.7 | |
*2/*2 | 15 | 22 | 14.8 | 21.5 | |
Total | 69 | 100 | 69 | 100 |