Table 4. Correlation between ESR1, CYP2C19, UGT2B15 polymorphisms and clinicopathological features.
ESR1 PvuII
|
CYP2C19
|
UGT2B15
|
|||||||
---|---|---|---|---|---|---|---|---|---|
wt/vt vt/vt | wt/wt | P | wt/wt | wt/*2 *2/*2 | P | wt/wt | wt/*2 *2/*2 | P | |
T stage | |||||||||
T1-2 | 43 | 18 | 0.15 | 51 | 10 | 0.68 | 15 | 46 | 0.09 |
T3-4 | 3 | 4 | 6 | 1 | 4 | 3 | |||
N stage | |||||||||
N0 | 34 | 16 | 0.51 | 41 | 9 | 0.43 | 13 | 37 | 0.51 |
N1 | 11 | 6 | 15 | 2 | 5 | 12 | |||
Grading | |||||||||
G1-2 | 20 | 6 | 0.31 | 21 | 5 | 0.59 | 6 | 20 | 0.31 |
G3 | 9 | 5 | 11 | 3 | 5 | 9 | |||
Histological type | |||||||||
Ductal | 30 | 11 | 0.49 | 32 | 9 | 0.04 | 14 | 28 | 0.27 |
Lobular | 11 | 5 | 16 | 0 | 3 | 12 | |||
ER status | |||||||||
0 | 12 | 6 | 0.55 | 15 | 3 | 0.62 | 7 | 11 | 0.22 |
1 | 35 | 16 | 42 | 9 | 13 | 38 | |||
PR status | |||||||||
0 | 9 | 11 | 0.01 | 18 | 2 | 0.25 | 7 | 14 | 0.40 |
1 | 38 | 11 | 39 | 10 | 13 | 35 | |||
HER2 status | |||||||||
0 | 31 | 12 | 0.54 | 36 | 7 | 0.49 | 14 | 28 | 0.34 |
1 | 7 | 2 | 7 | 2 | 2 | 8 | |||
Age | |||||||||
<50 yr. | 10 | 6 | 0.40 | 13 | 3 | 0.57 | 4 | 11 | 0.55 |
≥50 yr. | 37 | 16 | 44 | 9 | 16 | 38 | |||
Molecular subtype | |||||||||
Luminal A | 10 | 2 | 0.72 | 9 | 3 | 0.73 | 3 | 9 | 0.31 |
Luminal B (HER2-) | 9 | 2 | 10 | 1 | 3 | 8 | |||
Luminal B (HER2+) | 7 | 2 | 7 | 2 | 2 | 7 | |||
HER2+ | 0 | 0 | 0 | 0 | 0 | 1 | |||
Triple negative | 2 | 2 | 4 | 0 | 3 | 1 | |||
Recurrence | |||||||||
Yes | 40 | 13 | 0.02 | 43 | 10 | 0.43 | 13 | 40 | 0.12 |
No | 7 | 9 | 14 | 2 | 7 | 9 | |||
Death | |||||||||
Yes | 42 | 17 | 0.17 | 49 | 10 | 0.56 | 16 | 43 | 0.32 |
No | 5 | 5 | 8 | 2 | 4 | 6 |