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. 2013 Aug 8;8(8):e72219. doi: 10.1371/journal.pone.0072219

Table 4. Correlation between ESR1, CYP2C19, UGT2B15 polymorphisms and clinicopathological features.

ESR1 PvuII
CYP2C19
UGT2B15
wt/vt vt/vt wt/wt P wt/wt wt/*2 *2/*2 P wt/wt wt/*2 *2/*2 P
T stage
T1-2 43 18 0.15 51 10 0.68 15 46 0.09
T3-4 3 4 6 1 4 3
N stage
N0 34 16 0.51 41 9 0.43 13 37 0.51
N1 11 6 15 2 5 12
Grading
G1-2 20 6 0.31 21 5 0.59 6 20 0.31
G3 9 5 11 3 5 9
Histological type
Ductal 30 11 0.49 32 9 0.04 14 28 0.27
Lobular 11 5 16 0 3 12
ER status
0 12 6 0.55 15 3 0.62 7 11 0.22
1 35 16 42 9 13 38
PR status
0 9 11 0.01 18 2 0.25 7 14 0.40
1 38 11 39 10 13 35
HER2 status
0 31 12 0.54 36 7 0.49 14 28 0.34
1 7 2 7 2 2 8
Age
<50 yr. 10 6 0.40 13 3 0.57 4 11 0.55
≥50 yr. 37 16 44 9 16 38
Molecular subtype
Luminal A 10 2 0.72 9 3 0.73 3 9 0.31
Luminal B (HER2-) 9 2 10 1 3 8
Luminal B (HER2+) 7 2 7 2 2 7
HER2+ 0 0 0 0 0 1
Triple negative 2 2 4 0 3 1
Recurrence
Yes 40 13 0.02 43 10 0.43 13 40 0.12
No 7 9 14 2 7 9
Death
Yes 42 17 0.17 49 10 0.56 16 43 0.32
No 5 5 8 2 4 6