Table 4. Multicategory ROC analysis: ranking the absolute and relative cell densities according to overall discriminatory ability.

Rank	Marker alone	HUM1	Marker combined with TIC2	HUM
1	TIC	0.118	TIC/CD15rel 3	0.142
2	CD68	0.106	TIC/CD15	0.140
3	CD15	0.087	TIC/CD68rel	0.128
4	CD38	0.082	TIC/CD3	0.123
5	CD3	0.070	TIC/CD38 rel	0.122
6	CD68 rel	0.044	TIC/CD38	0.121
7	CD38 rel	0.037	TIC/CD20 rel	0.119
8	CD15 rel	0.032	TIC/CD3 rel	0.119
9	CD20	0.018	TIC/CD20	0.119
10	CD3 rel	0.0091	TIC/CD68	0.118
11	CD20 rel	0.0090	TIC	0.118
12	Null hypothesis4	0.0014	Null hypothesis4	0.0014

¹ HUM, hypervolume under the manifold, calculated according to ref. [12].

² TIC, total inflammatory cells (sum of CD3+, CD20+, CD38+, CD68+, and CD15+ cells per mm²).

³ Subscript rel: relative cell density of the respective marker. Absolute cell densities in all other cases.

⁴ HUM of a hypothetical nondiscriminatory marker, considering the number of classes and the presence of ties in this analysis.