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. Author manuscript; available in PMC: 2013 Aug 8.
Published in final edited form as: Neuron. 2007 Jun 21;54(6):919–931. doi: 10.1016/j.neuron.2007.05.029

Figure 7. Autism mutation of NL1 causes dominant-negative suppression of EPSCs.

Figure 7

(A) Representative traces of NMDA- (top) and AMPA-receptor dependent EPSCs (bottom). For a diagram of the mutants and a morphological analysis of the effect of the mutants on synapse density, see Suppl. Fig. 4. (B) Mean amplitudes of NMDA- and AMPA-receptor dependent EPSCs and mean NMDA/AMPA receptor ratios. Data shown are means ± SEMs (n=18 neurons from 3 cultures); asterisks indicate that a condition exhibits a statistically significant difference from the EGFP-only transfected control condition (* =p<0.05; **=p<0.01).