Table 3.

Morphologic patterns in dermal filler foreign body granuloma

Material	Trade name	Morphology	Host responsea
Hydroxyapatite	Radiance, Radiesse	25–50 um grey/green spherules	FBG 3
Hyaluronate	Restylane Juvederm	Basophilic lakes alcianophilic, hyaluronidase digestible	FBG 3
Liquid Silicone	Silicone medical grade	Adipocytoid vacuoles, variable size, 5–50 μm, vacant	FBG 3
Collagen Bovine	Zyplast Zyderm	Multilobular eosinophilic acellular coagulum	FN 1
Poly-L-lactate	New-Fill Sculptra	Angulate, elliptical particles of Equal size, refractilea	FBG 2
Polymethyl-methacrylate	Artecoll Artefill	Microspheres 40 μm, vacant	FBG 3
Hydroxyethyl-methacrylate	Dermalive	Translucent, broken glass-like nonrefractileb 20–120 μm Vacuoles	FBG 3
Polyacrylamide	Aquamid	Thin fibrous capsule	FN 2
Polyvinylhydroxide	Evolution	Microspheres 25–40 μm	FN 2

^aFN 1 foreign nodule, FN 2 foreign nodule chronic inflammation, FBG 3 foreign body granuloma with epithelioid histiocytes, multinucleated giant cells

^bRefractile = birefringent under crossed polars