Table 1.
Summary of Study Subjects
| Case | Control | |
|---|---|---|
| Genome Scanning | ||
| Number | 167 | 663 |
| Agea | 45.7 ± 15.2 | 53.5 ± 13.5 |
| Female ratio | 0.92 | 0.74 |
| Age at onseta | 30.5 ± 14.5 | NA |
| Genotyping | Illumina Infinium Human-Exome BeadChip | Illumina Infinium Human-Exome BeadChip |
| Subjects with clinical information | AR:87; CRP:89 | NA |
| Institutions | Kyoto University; Tokyo Women’s Medical University | Kyoto University |
| Replication Study | ||
| Number | 212 | 1,322 |
| Agea | 46.6 ± 17.6 | 53.3 ± 13.4 |
| Female ratio | 0.94 | 0.62 |
| Age at onseta | 27.0 ± 11.8 | NA |
| Genotyping | Taqman assay | Illumina Infinium Human Omni 2.5-4 BeadChip, Illumina Infinium Human Omni 2.5-8 BeadChip |
| Subjects with clinical information | AR:102; CRP:None | NA |
| Institutions | Tokyo Medical and Dental University; Kyoto University; Niigata University | Kyoto University |
Abbreviations are as follows: NA, not applicable; AR, aortic regurgitation; CRP, C-reactive protein.
a
Mean ± standard deviation (SD).