Table 2.

Results of Association Studies for TAK Susceptibility

SNP	Chr	Position	Gene	Ref(A1)	Var(A2)a	Genome Scan			Replication			Meta-analysis
						CaseA2freq	ContA2freq	p	CaseA2freq	ContA2freq	p	p	OR (95% CI)
rs10934853	3	129521063	EEFSEC	A	C	0.59	0.45	1.3 × 10−5	0.52	0.47	0.066	2.6 × 10−5	1.40 (1.20–1.64)
rs6871626	5	158759370	IL12B	C	A	0.53	0.37	1.8 × 10−7	0.53	0.39	1.1 × 10−7	1.7 × 10−13	1.75 (1.42–2.16)
rs9263739	6	31219335	CCHCR1	C	T	0.27	0.14	8.0 × 10−9	0.30	0.14	6.0 × 10−15	2.8 × 10−21	2.44 (2.03–2.93)
rs1570843	6	84577239	RIPPLY2	C	T	0.62	0.50	4.6 × 10−5	0.54	0.51	0.19	3.1 × 10−4	1.34 (1.14–1.57)
rs12102203	15	49578851	DMXL2	G	A	0.64	0.49	3.8 × 10−6	0.53	0.54	0.71	0.0081	1.24 (1.06–1.46)
rs665268	17	37975555	MLX	A	G	0.58	0.44	1.7 × 10−5	0.49	0.42	0.0032	5.2 × 10−7	1.50 (1.28–1.76)

Abbreviations are as follows: chr, chromosome; ref, reference allele; var, variant allele; CaseA2freq, variant allele frequency in cases; ContA2freq, variant allele frequency in controls; OR, odds ratio; CI, confidence interval. Positions are according to National Center for Biotechnology Information (NCBI) build 36.

^aRisk alleles for TAK based on the results of the genome scanning are set as variant alleles.