Table 2.
Genetic Association Results of the Most Significant SNP, rs10919543, in the FCGR2A/FCGR3A Locus and All Genetic Variants in High LD with This SNP
| SNP (Minor Allele) |
Turkish |
European-American |
Meta-analysis |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAFCase | MAFControl | OR | 95% CI | p | MAFCase | MAFControl | OR | 95% CI | p | OR | pmeta | Q Statistic p | |
| rs10919543 (G) | 0.559 | 0.413 | 1.80 | (1.47–2.22) | 1.49 × 10−8 | 0.462 | 0.320 | 1.82 | (1.35–2.46) | 6.71 × 10−5 | 1.81 | 5.89 × 10−12 | 0.952 |
| rs10919544 (C) | 0.560 | 0.413 | 1.81 | (1.47–2.22) | 1.50 × 10−8 | 0.458 | 0.325 | 1.75 | (1.30–2.36) | 0.0002012 | 1.79 | 1.61 × 10−11 | 0.874 |
| rs2099684 (G) | 0.554 | 0.415 | 1.75 | (1.43–2.15) | 7.17 × 10−8 | 0.458 | 0.323 | 1.77 | (1.32–2.39) | 0.0001497 | 1.76 | 5.70 × 10−11 | 0.951 |
| rs141730227 (T) | NA | NA | NA | NA | NA | 0.462 | 0.324 | 1.79 | (1.33–2.42) | 0.000131 | NA | NA | NA |
NA: The SNP rs141730227 was not evaluated in the Turkish cohort because the genotype success rate (GSR) of 0.898 was below our GSR threshold for SNP inclusion. However, when analyzed, it did show evidence for association (OR = 1.735 [1.397–2.155], p = 5.754 × 10−7).