Table 7.
Selective gene regulation by insulin and IGF-II.
| Transcript | Probe set (Affymetrix) | Accession nr. | FC insulin | p-Value insulin | FC IGF-II | p-Value IGF-II | FC IGF-I | p-Value IGF-I |
|---|---|---|---|---|---|---|---|---|
| Dusp6: dual specificity phosphatase 6 | 1415834_at | NM_026268 | 1.66 | 0.024401 | 4.45 | 0.000114 | 2.96 | 0.000037 |
| Nusap1: nucleolar and spindle associated protein 1 | 1416309_at | BC009096 | −1.61 | 0.000141 | −1.61 | 0.000022 | −1.14 | 0.097812 |
| Ndc80: NDC80 homolog, kinetochore complex component (S. cerevisiae) | 1417445_at | NM_023294 | −1.73 | 0.000121 | −1.61 | 0.000253 | −1.16 | 0.056240 |
| Ghr: growth hormone receptor | 1417962_s_at | NM_010284 | −1.67 | 0.008693 | −1.69 | 0.008944 | −1.15 | 0.197168 |
| Bhlhe40: basic helix-loop-helix family, member e40 | 1418025_at | NM_011498 | 1.66 | 0.005081 | 3.46 | 0.000576 | 2.42 | 0.000026 |
| Nfyb: nuclear transcription factor-Y beta | 1419267_at | AV250496 | 1.53 | 0.007996 | 1.60 | 0.005883 | 2.43 | 0.005169 |
| Areg: amphiregulin | 1421134_at | NM_009704 | 6.46 | 0.018404 | 32.85 | 0.001366 | 18.39 | 0.004443 |
| PQlc2: PQ loop repeat containing 2 | 1425632_a_at | BC019216 | 2.31 | 0.001027 | 2.12 | 0.001076 | 1.40 | 0.029326 |
| Cebpb: CCAAT/enhancer binding protein (C/EBP), beta | 1427844_a_at | AB012278 | 1.74 | 0.018553 | 1.80 | 0.005586 | 1.13 | 0.445063 |
| Sema3c: sema domain, immunoglobulin domain (Ig), short basic domain, secreted (semaphorin) 3C | 1429348_at | AK004119 | −1.70 | 0.006766 | −1.72 | 0.008802 | 1.03 | 0.733222 |
| Cyld: cylindromatosis (turban tumor syndrome) | 1429617_at | BM119209 | −1.61 | 0.005787 | −1.50 | 0.003897 | −1.03 | 0.807135 |
| Bop1: block of proliferation 1 | 1430491_at | AV128350 | 1.78 | 0.013556 | 1.93 | 0.006039 | 1.04 | 0.820081 |
| Rhobtb3: Rho-related BTB domain containing 3 | 1433647_s_at | BM942043 | −1.62 | 0.027000 | −1.64 | 0.022981 | −1.02 | 0.890963 |
| Sc5d: sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) | 1434520_at | AU067703 | 2.18 | 0.006626 | 2.25 | 0.001725 | 3.34 | 0.000004 |
| Foxp1: forkhead box P1 | 1435222_at | BM220880 | −2.10 | 0.010890 | −1.94 | 0.017867 | −1.44 | 0.055486 |
| Kif11: kinesin family member 11 | 1435306_a_at | BM234447 | −1.92 | 0.003119 | −1.76 | 0.006149 | −1.20 | 0.115116 |
| Ppm2c: protein phosphatase 2C, magnesium dependent, catalytic subunit | 1438201_at | AV290622 | −2.18 | 0.000445 | −1.54 | 0.028117 | 1.05 | 0.650024 |
| Matr3: Matrin 3, mRNA (cDNA clone MGC:28206 IMAGE:3989914) | 1441272_at | BI249188 | 2.63 | 0.004643 | 2.78 | 0.000614 | 1.72 | 0.006058 |
| Kif11: kinesin family member 11 | 1452314_at | BB827235 | −2.02 | 0.003923 | −1.54 | 0.017306 | 1.11 | 0.406989 |
| Kif11: kinesin family member 11 | 1452315_at | BB827235 | −1.85 | 0.000158 | −1.83 | 0.000706 | −1.13 | 0.347961 |
Transcripts that fulfilled the criteria of 1.2 and 0.05 for fold change and p-value respectively for insulin and IGF-II versus the control and versus IGF-I were selected. The transcripts were then filtered for a fold change of 1.5 in comparison to the control. Transcripts that also fulfilled the criteria for IGF-I versus the control are in italic. FC, fold change.