Fig. 1.
Percent of Dox released for Doxil and DPPC/MSPC (10%) at t = 4 minutes. Comparison of doxorubicin release after 4 minutes of heating across a range of temperatures for LTSL-Dox (DPPC/MSPC (10%)) versus Doxil. LTSL-Dox releases drug in the temperature range between 39.5°C and 42°C, which is in the range that can be achieved for routine application of hyperthermia. Maximal release occurs at the phase transition temperature of 41.3°C. DPPC - Dipalmitoylphosphatidylcholine; MSPC - Monostearoylphosphatidylcholine.