Contrast-enhanced computed tomography scans of hepatic lesions, before and after RF ablation, combined with LTLD. (A) Appearance of metastatic adrenal cell carcinoma, before and several months after thermal ablation. Note that the ablation zone enlarges and stabilizes after treatment. (i) Before treatment (arrow), (ii) 3 days after treatment, (iii) 4 weeks after treatment, (iv) 11 weeks after treatment, (v) 20 weeks after treatment. (B) Appearance of 2 primary HCCs, before and after thermal ablation. (Courtesy of Brad Wood and Celsion Corporation, Lawrenceville, NJ; Images (i), (ii), and (v) in (A) Reprinted from Wood BJ, Poon RT, Locklin JK, et al. Phase I study of heat-deployed liposomal doxorubicin during radiofrequency ablation for hepatic malignancies. J Vasc Interv Radiol 2012;23(2):248–55.e7, with permission from author and publisher; and Images (iii) and (iv) in (A) were kindly provided by the Celsion Corporation.)