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Iron-mediated colorectal cancer (CRC) progression. Through increased iron acquisition by DMT-1 from the diet or holo-Tf-TfR1 from the circulation, and decreased iron export by hepcidin-mediated degradation of FPN or decreased FPN expression, iron accumulation in colon tumors leads to an increase in reactive oxygen species (ROS) production, oncogene activation, pro-inflammatory mediators and dysbosis which contribute to an increase in the growth of CRC.
