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Effects of PTIF on serum alkaline phosphatase (ALP) (A), collagen type I (CTx) (B), osteocalcin (OC) (C) and estradiol (D) levels. Data are the mean ± SEM values (n = 12 per group). * p < 0.05 and *** p < 0.001, significantly difference from the OVX-control group.
