Table 2.
Relationship between hypoxia-related proteins and clinicopathological variables
| No. of expression(%) | |||||
|---|---|---|---|---|---|
| Variables | n | HIF-1α | GLUT-1 | CA-9 | iNOS |
| Age | |||||
| <60 | 118 | 64(54.2) | 42(35.6) | 65(55.1) | 49(41.5) |
| ≥60 | 75 | 37(49.3) | 41(54.7) | 45(60.0) | 34(45.3) |
| p value | 0.506 | 0.009* | 0.501 | 0.602 | |
| Gender | |||||
| male | 123 | 63(51.2) | 49(39.8) | 66(53.7) | 51(41.5) |
| female | 70 | 38(54.3) | 34(48.6) | 44(62.9) | 32(45.7) |
| p value | 0.682 | 0.239 | 0.215 | 0.566 | |
| Histologic type | |||||
| differentiated | 108 | 57(52.8) | 51(47.2) | 61(56.5) | 37(34.3) |
| less-differentiated | 85 | 44(51.8) | 32(37.6) | 49(57.6) | 46(54.1) |
| p value | 0.889 | 0.182 | 0.871 | 0.006* | |
| Lauren classification | |||||
| intestinal | 130 | 71(54.6) | 64(49.2) | 71(54.6) | 49(37.7) |
| diffuse | 63 | 30(47.6) | 19(30.2) | 39(61.9) | 34(54.0) |
| p value | 0.362 | 0.012* | 0.337 | 0.032* | |
| pT | |||||
| T1 | 81 | 37(45.7) | 28(34.6) | 43(53.1) | 25(30.9) |
| T2-4 | 112 | 64(57.1) | 55(49.1) | 67(59.8) | 58(51.8) |
| p value | 0.116 | 0.044* | 0.351 | 0.004* | |
| pN | |||||
| N0 | 107 | 47(43.9) | 37(34.6) | 62(57.9) | 40(37.4) |
| N1-3 | 86 | 54(62.8) | 46(53.5) | 48(55.8) | 43(50.0) |
| p value | 0.009* | 0.008* | 0.766 | 0.078 | |
| Stage | |||||
| I | 91 | 41(45.1) | 30(33.0) | 51(56.0) | 29(31.9) |
| II | 42 | 21(50.0) | 18(42.9) | 22(52.4) | 20(47.6) |
| III | 60 | 39(65.0) | 35(58.3) | 37(61.7) | 34(56.7) |
| p value | 0.053 | 0.009* | 0.627 | 0.008* | |
* statistically significant