Phosphorylated GSK3 α/β immunoreactivity in the frontal cortex (CX) and CA1 (HPC) of rTg4510 scramble Aβ (Sc Aβ, A, B) or OLIGO (C, D) is presented. Staining density was analysed as percent of stained area is represented as ratio of the ipsilateral to the contralateral side for each region after treatment (E, F). Scale bar is 200μm. * p< 0.05; ** p< 0.01, n=5.