. Author manuscript; available in PMC: 2013 Dec 3.

Published in final edited form as: Angew Chem Int Ed Engl. 2012 Nov 4;51(49):12263–12267. doi: 10.1002/anie.201207603

Table 1.

Functional Properties of intact and N-terminal PTHrP peptide ligands

ligand	Binding						n	cAMP (Glosensor assay)
	R0		P	RG				cAMP (Glosensor assay)
	pIC₅₀			pIC₅₀		P		Emax	p	pEC₅₀		p	n
	nM	fold		nM	fold	P		fold-basal^a	p	nM	fold	p	n
PTHrP(1–37)-OH	8.40 ± 0.12		1.00	9.98 ±0.10		1.00	4	161 ± 21	1.000	9.68 ± 0.37		1.000	3
	3.98	1.0		0.105	1.0					0.21	1.0
PTHrP(1–141)-OH	7.53 ± 0.11		0.002	8.66 ± 0.08		0.0001	4	175 ± 20	0.670	9.39 ± 0.39		0.610	3
	29.51	7.4		2.19	21					0.41	2.0

Basal = 1.223±145 cps, n=3