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. 2010 Dec 13;13(2):242–247. doi: 10.1038/aja.2010.100

Table 5. Studies on the expression and localisation of the SSTRs in human prostate tissue.

Authors and reference Year Technique Receptors Localisation Type of tissue
Reubi et al.20 1995 Autoradiography, in situ hybridisation SSTR1 Smooth muscle, endothelium BPH and PCa
      SSTR2    
      SSTR3    
Halmos et al.23 2000 RT-PCR SSTR1 Epithelial cells PCa
      SSTR2    
      SSTR5    
Dizeyi et al.7 2002 IHC, RT-PCR, Western blot SSTR1 Epithelial cells, stromal cells, endothelium Normal, BPH, PCa
      SSTR2    
      SSTR3    
      SSTR4    
      SSTR5    
Hansson et al.19 2002 In situ hybridisation SSTR2 Epithelial cells, stromal cells BPH PIN, PCa
      SSTR4    
Volante et al.24 2007 IHC SSTR2A Epithelial cells Cancer
      SSTR3    
      SSTR5    
Montironi et al.11 2008 IHC SSTR1 Secretory cells, basal cells, smooth muscle stromal cells, endothelial cells BPH
      SSTR2    
      SSTR3    
      SSTR4    
      SSTR5    
Cariaga-Martinez et al.22 2009 IHC SSTR2 Luminal side of duct and acinar cells Normal, BPH and PCa
Morichetti et al.10 2010 IHC SSTR1 Secretory cells, basal cells, smooth muscle stromal cells, endothelial cells Normal, HGPIN and incidental PCa
      SSTR2    
      SSTR3    
      SSTR4    
      SSTR5    
Morichetti et al.9 2010 IHC SSTR1 Secretory cells, basal cells, smooth muscle stromal cells, endothelial cells PCa with NE differentiation
      SSTR2    
      SSTR3    
      SSTR4    
      SSTR5    
Mazzucchelli et al.8 2010 IHC SSTR1 Secretory cells, basal cells, smooth muscle stromal cells, endothelial cells Complete androgen-ablated PCa
      SSTR2    
      SSTR3    
      SSTR4    
      SSTR5    
Mazzucchelli et al. (the present study) 2010 IHC SSTR1 Secretory cells, smooth muscle stromal cells, endothelial cells Hormone-refractory PCa
      SSTR2    
      SSTR3    
      SSTR4    
      SSTR5    

Abbreviations: BPH, benign prostatic hyperplasia; HGPIN, high grade prostatic intraepithelial neoplasia; IHC, immunohistochemistry; NE, neurendocrine; PCa, prostate cancer; PIN, prostatic intraepithelial neoplasia; RT-PCR, real-time polymerase chain reaction; SSTR, somatostatin receptors.