Table 3. Overall abnormal promoter methylation in different groups.
| Normal P1/P2 (n=10) | High P1/P2 (n=10) | Low P1/P2 (n=10) | Combined infertile group | P value | ||
|---|---|---|---|---|---|---|
| Overall abnormal methylation (%) | Between all groups | Fertile versus infertile groups | ||||
| OCT4 | 4.77 | 3.73 | 5.97 | 4.85 | 0.1039 | 0.5804 |
| SOX2 | 0.50 | 0.28 | 0.17 | 0.22 | 0.4304 | 0.2371 |
| NANOG | 13.89a | 10.50 | 14.00 | 12.25 | 0.9904 | 0.9431 |
| HOXC11 | 0.58 | 0.58 | 0.37 | 0.47 | 0.4802 | 0.5003 |
| miR-17 | 0.12 | 0.06 | 0.29 | 0.18 | 0.1174 | 0.5659 |
| CREM | 0.46 | 1.21 | 0.73 | 1.11 | 0.3702 | 0.5561 |
Abbreviation: P1/P2, protamine 1/protamine 2.
a
Only nine donor samples were included in the analysis.