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. Author manuscript; available in PMC: 2014 Jan 18.
Published in final edited form as: Nature. 2013 Jul 18;499(7458):301–305. doi: 10.1038/nature12343

Figure 1. Muscle-specific expression of Myomaker.

Figure 1

a, In situ hybridization for Myomaker in WT embryos illustrates muscle specificity. b, qPCR for Myomaker, Myogenin, and MyoD on tongues at the indicated ages shows down-regulation after myogenesis. c, Gene expression during differentiation of C2C12 myoblasts. d, X-gal staining on E16 and P2 Myomaker+/− (Myomaker-LacZ) mice confirms expression in all skeletal muscles. e, Cardiotoxin-injured and X-gal stained tibialis anterior (TA) muscle from 6 week old Myomaker+/− mice shows the re-activation of Myomaker. Serial H&E stained sections indicate muscle injury. Control represents uninjured contralateral TA. Scale bars: a, d, 2 mm; e 200 µm.