Table 5. Analysis of genotype frequencies of NOS2 gene polymorphisms, based on small and large prostatic volume, in subjects with BPH.
| SNP (locus) | Genotype | Prostatic volume (mL) |
Model | OR (95% CI) | P-value | |
|---|---|---|---|---|---|---|
| < 30 mL |
≥ 30 mL |
|||||
| n = 99 (%) | n = 130 (%) | |||||
| rs2779248 | T/T | 85 (85.9) | 97 (74.6) | Codominant | 1.99 (1.08–3.65) | 0.020 |
| Promoter | T/C | 13 (13.1) | 27 (20.8) | Dominant | 2.11 (1.05–4.23) | 0.031 |
| −278 | C/C | 1 (1.0) | 6 (4.6) | Recessive | 4.49 (0.53–38.38) | 0.110 |
| rs10459953 | G/G | 14 (14.1) | 52 (40.0) | Codominant | 0.44 (0.29–0.65) | < 0.0001 |
| 5′UTR | C/G | 54 (54.5) | 55 (42.3) | Dominant | 0.23 (0.12–0.46) | < 0.0001 |
| C/C | 31 (31.3) | 23 (17.7) | Recessive | 0.46 (0.24–0.86) | 0.015 | |
| rs2297518 | G/G | 75 (75.8) | 93 (71.5) | Codominant | 1.40 (0.80–2.43) | 0.230 |
| Missense | A/G | 24 (24.2) | 32 (24.6) | Dominant | 1.26 (0.69–2.31) | 0.460 |
| Ser608Leu | A/A | 0 (0.0) | 5 (3.8) | Recessive | 0.057* | |
Abbreviations: 5′UTR, 5′-untranslated region; BPH, benign prostatic hyperplasia; CI, confidence interval; n, number of subjects; NOS2, nitric oxide synthase 2; OR, odds ratio; SNP, single nucleotide polymorphism.
Note: P-values were obtained from logistic regression analyses with the codominant, dominant and recessive models without Bonferroni correction.
*
P-value was tested using Fisher's exact test.