Table 3. ICSI and embryo transfer outcomes for HBV-positive and HBV-negative groups.
| Variable | Positive (n=325) | Negative (n=325) | P value |
|---|---|---|---|
| Age of wives (year) | 31.4±4.3 | 31.5±4.3 | NS |
| Female BMI (kg m−2) | 22.1±2.9 | 22.1±3.2 | NS |
| Duration of infertility (year) | 4.9±3.1 | 5.0±3.3 | NS |
| Times of IVF–ET/ICSI–ET (cycle) | 1.2±0.5 | 1.3±0.6 | NS |
| Primary infertility (n, %) | 163 (50.1) | 159 (48.9) | NS |
| Distribution of infertile factors (n, %) | |||
| Total number of husbands with sperm problems | 305 (93.8) | 294 (90.5) | NS |
| Total number of wives with tubal blockage | 163 (50.2) | 177 (54.5) | NS |
| Total number of wives with ovulation failure | 12 (3.7) | 14 (4.3) | NS |
| Total number of wives with endometriosis | 28 (8.6) | 19 (5.8) | NS |
| Total number of couples with unexplained infertility | 10 (3.1) | 10 (3.1) | NS |
| Duration of stimulation (day) | 9.7±2.0 | 9.4±2.0 | NS |
| Total dose of gonadotropin used (IU) | 2572±1003 | 2570±1075 | NS |
| Serum E2 levels on day of hCG injection (pmol l−1) | 1 1509±7075 | 1 2212±7495 | NS |
| No. of retrieved oocytes | 13.1±6.9 | 12.8±6.5 | NS |
| No. of embryos transferred in cycles by ET | 2.3±0.5 | 2.3±0.6 | NS |
| 2PN fertilisation rate (%) | 2445/3448 (70.9) | 2463/3328 (74.0) | 0.005 |
| High-grade embryo rate (%) | 1405/2439 (57.6) | 1452/2403 (60.4) | 0.046 |
| Implantation rate (%) | 126/688 (18.3) | 159/657 (24.2) | 0.008 |
| Clinical pregnancy rate (%) | 96/308 (31.2) | 118/300 (39.3) | 0.035 |
| Cancellation rate (n, %) | 17 (5.2) | 25 (7.6) | NS |
Values are presented as mean±s.d.
Abbreviations: BMI, body mass index; E2, estradiol; ET, embryo transfer; HBV, hepatitis B virus; hCG, human chorionic gonadotrophin; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilisation; NS, not significant; 2PN, two-pronuclear.