Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of the canonical extracellular signal regulated protein kinases (ERK) phosphorylation by sorafenib treatment. Prostate cancer cells were exposed to the drug at the indicated concentrations for 4 h. The cells were then lysed and the lysates were analyzed by Western blot for phosphorylated-ERK (p-ERK), using total ERK levels as an internal control. The morphological pictures represent PC-3, LNCap, and DU145 cells treated with 10 μmol L−1 sorafenib for 24 h.
