Table 2.
Cancer Incidence Rates Within 10 Years After Combination Antiretroviral Therapy Initiation, Centers for AIDS Research Network of Integrated Clinical Systems, 1996–2011
| Incidence Rate per 100 000 Person-years (95% CI) |
||||
|---|---|---|---|---|
| Cancer Type | Total No. | 0–10 y | 0–6 mo | 6 mo–10 y |
| Overall | 457 | 987 (900–1081) | 2405 (2030–2848) | 793 (711–884) |
| ADC | 241 | 515 (454–584) | 1881 (1554–2278) | 330 (279–390) |
| KS | 143 | 304 (258–358) | 1342 (1071–1683) | 164 (129–208) |
| NHL non-CNS | 76 | 161 (128–201) | 357 (230–553) | 134 (103–175) |
| NHL CNS | 19 | 40 (26–63) | 160 (84–308) | 24 (13–44) |
| Cervicala | 3 | 30 (10–92) | … | … |
| NADC | 216 | 466 (408–533) | 520 (362–749) | 459 (398–530) |
| Virus-related NADCs | 89 | 192 (156–237) | 251 (149–424) | 184 (147–231) |
| Squamous cell anal | 32 | 69 (49–98) | 72 (27–191) | 69 (47–100) |
| Hodgkin lymphoma | 27 | 58 (40–85) | 144 (72–287) | 47 (30–73) |
| Liver | 17 | 37 (23–59) | 18 (3–127) | 39 (24–64) |
| Squamous cell oral cavity/pharynx | 9 | 19 (10–37) | … | … |
| Otherb | 4 | 9 (3–23) | … | … |
| Virus-unrelated NADCs | 127 | 274 (230–326) | 269 (162–447) | 275 (228–331) |
| Lung | 26 | 56 (38–82) | 54 (17–167) | 56 (38–85) |
| Prostatea | 20 | 54 (35–83) | 22 (3–159) | 58 (37–91) |
| Breasta | 13 | 128 (75–221) | 177 (44–708) | 122 (68–221) |
| Melanoma | 10 | 22 (12–40) | … | … |
| Colorectal | 8 | 17 (9–35) | … | … |
| Kidney | 5 | 11 (5–26) | … | … |
| Otherc | 45 | 93 (69–125) | … | … |
| Lymphomasd | 122 | 259 (217–309) | 660 (479–912) | 205 (165–253) |
| HPV-related cancerse | 48 | 104 (78–138) | 108 (48–140) | 103 (76–140) |
Only overall incidence rates were calculated for cancer types with ≤10 cases.
Abbreviations: ADC, AIDS-defining cancer; CI, confidence interval; CNS, central nervous system; HPV, human papillomavirus; KS, Kaposi sarcoma; NADC, non-AIDS-defining cancer; NHL, non-Hodgkin lymphoma.
a Cervical cancer and breast cancer incidence calculated only among women. Prostate cancer incidence calculated only among men.
b Other virus-related cancers include penile, vaginal, and vulvar.
c Other virus-unrelated cancers include bladder, brain, esophagus, larynx, leukemia, multiple myeloma, ovary, pancreas, peritoneum, small intestine, soft tissue, stomach, testicular, uterus, or non–squamous cell oral cavity/pharynx.
d Lymphomas included NHL non-CNS, NHL CNS, and Hodgkin lymphoma.
e HPV-related cancers included cervical, squamous cell anal (which includes squamous cell anorectal cancer), squamous cell oral cavity/pharynx, penile, vaginal, and vulvar cancer.