Table 1A.

JC Virus DNA copy number in ≥ 3 CSF samples and plasma/serum including antiviral antibody

Patient (ref # LN)	Treatment History	Sample collection date #	CSF viral copies	Plasma/serum viral copies/ antibody titer
Persistent Viral Load
EEA
1	PLEX, CDV	6/15/09*	415c/ml	NA*
		7/3/09	745c/ml	NA
		9/4/09	201c/ml	NA
2 (#4)	IA, mefloquine	11/26/08	69c/ml
		12/5/08	215c/ml	426c/ml s	2,560
		1/19/09	117c/ml	19c/ml s	10,240
		1/28/09	181c/ml	329c/ml s	40,960
		3/12/09	48c/ml	61c/ml s	163,840
		4/24/09	26c/ml	Und p	163,840
				Und s
3 (#9)	IA, IVIG, mirtazipine	4/17/09	68c/ml
		5/13/09	50c/ml
		6/10/09	134c/ml
		7/22/09	3879c/ml	2640c/ml s	40,960
		10/14/09	89c/ml	79c/ml s	2,621,440
4	Plex,	9/29/09	35c/ml
(#18)	mefloqine,	10/12/09	66c/ml	49c/ml p	40,960
	mirtazipine			30c/ml s
		10/21/09	155c/ml	295c/ml p	163,840
				396c/ml s
		11/4/09	81c/ml	87c/ml p	2,261,440
				111c/ml s
		11/18/09	75c/ml	148c/ml p	2,261,440
				95c/ml s
		12/8/09	21c/ml	27c/ml p	2,261,440
		3/8/10	12c/ml	Und p	2,261,440
				Und s
5	PLEX,	11/26/09	41c/ml	NA
(#5)	mefloquine	12/7/09	126c/ml	NA
		12/16/09	227c/ml	NA
USA
64	PLEX, Ara C,	3/2/05	6,050c/ml	2500c/ml s	40,960
	CDV	3/29/05	2,275c/ml	und s	655,360
		9/20/05	42c/ml	und s	655,360
		6/11/08	37c/ml	14c/ml p
		9/12/08	26c/ml	108c/ml p
7	PLEX	10/9/09	40,646c/ml	und s	10,240
(#23)		11/3/09	101,900c/ml
		11/17/09	769,000c/ml
Decreased Viral Load
EEA
8	PLEX	4/7/09	96,436c/ml	463c/ml p	10,240
(#6)				275c/ml s
		4/21/09	601,825c/ml	12,487c/ml p	40,960
	10,812c/ml s	5/5/09	2,241,062c/ml	10,900c/ml p	40,960
	8,350c/ml s	5/29/09	3,482,575c/ml	18,012c/ml p	40,960
				21,875c/ml s
		7/16/09	13,825c/ml	4,063c/ml p	10,485,760
		9/3/09	1,114c/ml	1,100c/ml p	10,485,760
				1.374c/ml s
USA
9	PLEX,	5/18/09	1,220,175c/ml	NA
(#7)	mefloquine	6/2/09	444,325c/ml	NA
		7/7/09	9,937c/ml	NA
Decreased to Undetected Viral Load
EEA
105	PLEX, IA,	7/24/08	53c/ml	NA
(#1)	mefloquine	8/15/08	10c/ml	NA
		8/28/08	Und	12c/ml p	163,840
11	PLEX,	10/9/2009	11c/ml	NA
(#28)	mefloquine	1/8/2010	26c/ml	6c/ml s	655,360
		3/16/2010	und	und s	163,840
12	PLEX, IVIG,	12/22/09	51c/ml	NA
	mefloquine,	1/26/09	39c/ml	NA
	mirtazipine	2/25/09	70c/ml	NA
		3/25/10	9c/ml
		4/12/10	und
13	PLEX,	9/9/09	1387c/ml	28c/ml p	40,960
(#15)	mefloquine,			18c/ml s	655,360
	mirtazipine	10/7/09	169c/ml	26c/ml p	655,360
		1/29/10	Und	und p/s

^*First date indicates sample at time of PML diagnosis.

NA: Sample(s) Not Available. P plasma; s serum. Antibody titers are ≥ reported value

Und: Undetected in qPCR assay

(#) refers to patient number and information in reference # 2

Patients’ 6 and 10 information are in refs 4 and 5 respectively.

EEA European Economic Area; USA United States of America

PLEX: plasma exchange; IA: immune absorption; CDV: cidofovir; Ara C: cytosine arabinoside