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. 2013 Aug;19(8):1285–1288. doi: 10.3201/eid1908.121498

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This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

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Recombination analysis of complete genome of coxsackievirus A2 (CVA2), Hong Kong, 2012. A) Genome organization. B) Bootscanning and C) similarity plot analyses were conducted by using Simplot version 3.5.1 (http://sray.med.som.jhmi.edu/SCRoftware/simplot/) (Kimura distance model; window size, 400 bp; step, 20 bp) on a gapless nucleotide alignment generated with ClustalX 2.0 (8) with the genome sequence of CVA2 strain 430895 as the query sequence. In panel B, green line indicates CVA2 prototype strain Fleetwood, red line indicates EV71 strain SAR/SHA66 of subgenotype B3, yellow line indicates EV71 strain SZ/HK08–5 of subgenotype C4, and blue line indicates CVA4 strain SZ/CHN/09. P1, capsid protein 1, P2, nonstructural protein 2; P3, nonstructural protein 3; UTR, untranslated region; VP, viral protein.