Pain at ejaculation, haemospermia and premature ejaculation in patients in the Cipro-750 (grey bars) and Cipro-500 (black bars) treatment groups. After the assessment of microbiological eradication (time point VERAD), patients were examined every 6 months during an 18-month follow-up period (V6–V18). The percentage of patients with individual symptoms is presented. Frequency of pain at ejaculation in Cipro-500 vs. Cipro-750 treatment groups between baseline (V0) and microbiological eradication (VERAD) time points: χ2=0.16, P=0.68. Frequency of haemospermia in Cipro-500 vs. Cipro-750 treatment groups between baseline (V0) and microbiological eradication (VERAD) time points: χ2=0.75, P=0.38. Frequency of premature ejaculation in Cipro-500 vs. Cipro-750 treatment groups between baseline (V0) and microbiological eradication (VERAD) time points: χ2=1.91, P=0.16; between V0 and V6: χ2=11.64, P=0.0006; between VERAD and V6: χ2=4.96, P=0.025.