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. 2011 Jun 6;13(5):732–741. doi: 10.1038/aja.2011.11

Figure 3.

Figure 3

Stromal cells stimulate the proliferation, migration and invasion of prostate epithelial cells in vitro in an age-related manner. Proliferation of BPH-1 (a) and PC-3 (b) in stromal cell-conditioned medium was measured using a CCK-8 assay. Stimulation by stromal cells was performed for 96 h. The mean values of four independent measurements±s.d. are shown. *P<0.01, compared with other two groups. (c) Migration assays showed that both BPH-1 and PC3 cells migrated faster when cocultured with PZ-old cells (*P<0.01: PZ-old groups versus PZ-young or control group; **P<0.05: PZ-young groups versus control group). (d) Invasion index of PC-3 cells through GFR-MatriGel-coated transwell filters. There was no difference in the invasion index of the PC-3/PZ-young group and that of the PC-3 group; the invasion index of PC-3/PZ-old was significantly higher than those of the other two groups (*P<0.01). CCK-8, Cell Counting Kit-8; PZ, peripheral zone.