Table 3.

Prevalence of bone density below treatment T-score cutpoint and corresponding threshold weights for screen and treat strategy to be cost-effective for women without prior clinical fracture (societal WTP=$75,000 per QALY gained)

Age (years)	Mean weight (kg)*	Prevalence BMD below Rx threshold (%)**	Drug cost $500 per year		Drug cost $250 year
			Cost-effective pre-test probability (%)^	Threshold weight (kg)^^	Cost-effective pre-test probability (%)	Threshold weight (kg)
55	78.5	0.93	1.62	73.8	1.45	74.7
60	79.1	2.76	1.49	84.9	1.35	85.8
65	76.6	4.42	1.23	90.5	1.16	91.1
70	74.0	8.16	1.13	97.6	1.04	98.5
75	68.7	14.59	1.15	99.4	1.09	100.1
80	66.4	19.21	1.23	100.2	1.15	101.0

^*Ten-year hip fracture risk treatment threshold varied from 6 to 3%

^**Odds ratio of femoral neck osteoporosis per 10-kg increase body weight varied from 0.22 to 0.65

^***Fracture disutility varied from 50 to 150% of base case value

^{^}Fracture costs varied from 70 to 130% of base case value

^{^^}Fracture rates varied from 80 to 120% of base case value