Table 1. Information retrieval and mutation extraction in three test cases.

Sequence	Keywords*	Abstractsretrieved	Abstracts with mutations	Number of mutations
PTEN_HUMAN	“PTEN”, “PHOSPHATASE AND TENSIN HOMOLOG”, “MMAC1”, “TEP1”	6001	297	435
GLPA_HUMAN	“GLYCOPHORIN-A”, “MN SIALOGLYCOPROTEIN”,“SIALOGLYCOPROTEIN ALPHA”, “GYPA”, “GPA”	8837	95	183
CHEY_ECOLI	“CHEMOTAXIS PROTEIN CHEY”,”CHEY”	933	51	103

^*These are the keywords that MutationMapper automatically extracted from Uniprot and used to search PubMed.