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. 2013 Aug 9;8(8):e73366. doi: 10.1371/journal.pone.0073366

Figure 5. Effect of ST8SiaII inhibition on tumour cell migration.

Figure 5

Effect of CMP treatment on the migration of C6-STX, C6-WT, SH-SY5Y, and DLD-1 cells as assessed by 2D migration assays. Confluent cell monolayers were incubated with fresh complete medium and re-population of scratched wounds after 24 h was assessed. Migration is expressed as a percentage of that observed with untreated cells for a given cell line (complete re-population). CMP treatment at all concentrations decreased the migration capacity of polySia-expressing SH-SY5Y and C6-STX cells in a concentration dependent manner. However, CMP treatment had no significant effect on the migration of C6-WT and DLD-1 cells even at high concentrations. C6-WT and DLD-1 cells do not express polySTs or polySia. Values shown are means ± S.D based on three independent experiments (* P < 0.01).