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. 2013 Aug 9;8(8):e70828. doi: 10.1371/journal.pone.0070828

Figure 1. PTP1B−/− mice are resistant to DSS-induced colitis.

Figure 1

A) The colon tissue of WT and PTP1B−/− mice that received either control water or water containing 2.5% DSS for 2 weeks. B) Representative H&E-stained mouse distal colonic sections on day 8 after treatment. C) Disease activity index after the beginning DSS treatment. D) The survival rate of mice during the course of DSS treatment. E-F) The relative activity of MPO (E) and the labeling with anti-F4/80 antibody (F) in colon from mice treated with or without DSS (on day 8). G) Serum cytokine concentrations in WT and PTP1B−/− mice after 8 days of DSS treatment. Data are representative of 3 replicated experiments that produced similar results (n = 6 per group per condition). *, p<0.05, **, p<0.01.