Figure 2. Increased functional MDSCs in PTP1B^−/− mice.

A) The frequency of CD11b⁺Gr-1⁺ MDSCs in bone marrow of WT and PTP1B^−/− mice after DSS treatment for 8 days. B) The frequency of CD11b⁺Gr-1⁺ MDSCs in the spleens and blood of WT and PTP1B^−/− mice after DSS treatment for 8 days. C) The increased MDSCs in the spleen of PTP1B^−/− mice are both monocytic and neutrophil origin. D) The induced MDSCs in both PTP1B^−/− mice and WT mice inhibit T cell proliferation. Data are representative of 3 replicated experiments with similar results (n = 5 per group per condition). Compared with WT-DSS, *, p<0.05, **, p<0.01.